People

Portrait of Prof. Chunliang (Leon) Xu speaking at a conference, gesturing with a presentation clicker

Chunliang (Leon) Xu, PhD

Professor & Principal Investigator

Humoral immune memory, long-lived plasma cell survival in bone marrow and mucosal niches, and durable vaccine design

Dr. Chunliang (Leon) Xu is a Professor at the Zhongshan School of Medicine, Sun Yat-sen University, and a PhD supervisor. His research group focuses on the maintenance and function of long-lived plasma cells, and his laboratory is affiliated with the Key Laboratory for Stem Cells and Tissue Engineering (Ministry of Education). He earned his PhD in Cell Biology from the Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences / Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine, under the mentorship of Professor Yufang Shi. He completed his postdoctoral training at Columbia University (Prof. Remi Creusot, 2013–2014) and the Albert Einstein College of Medicine (Prof. Paul Frenette, 2014–2018), where he subsequently served as Associate (2018–2021). Prior to joining Sun Yat-sen University in 2022, Dr. Xu served as Assistant Professor at The Chinese University of Hong Kong (2021–2022). He has authored high-impact publications in leading journals, including Nature, Nature Medicine, Immunity and Cell Stem Cell, and his research work has been cited more than 7,300 times (Google Scholar). He is dedicated to deciphering the cellular and molecular mechanisms that govern the establishment and maintenance of long-lived plasma cells in bone marrow and mucosal niches.

Postdoctoral Fellows

Portrait of Yiming Zhu

Yiming Zhu

Postdoctoral Fellow

Yiming Zhu is from Shandong, China. She holds a bachelor’s degree from Jiangnan University, a master’s degree from the National University of Singapore and a PhD from Sun Yat-sen University. Her research in the Xu Lab focuses on the mechanisms that keep long-lived plasma cells alive and resident in the bone marrow. Outside the lab, she enjoys seeking out new restaurants and cafés.

Portrait of Chumei Zeng

Chumei Zeng

Postdoctoral Fellow

Chumei Zeng is from Nanning, Guangxi, China. She holds bachelor’s and master’s degrees in Clinical Medicine from Guangxi Medical University and a PhD in Obstetrics and Gynecology from the First Affiliated Hospital of Sun Yat-sen University. Her research in the Xu Lab focuses on pregnancy immunology. Outside the lab, she enjoys road cycling, tennis, surfing and hiking.

PhD Students

Portrait of Hui Xu

Hui Xu

PhD Candidate

Hui Xu is from Wuwei, Gansu Province, China. She holds a bachelor’s degree from Xinjiang Medical University and a master’s degree from Southern Medical University. Her research in the Xu Lab focuses on mucosal immunology, in particular how intestinal IgA plasma cells are maintained through their interactions with the local tissue microenvironment. Outside the lab, she enjoys yoga, Pilates and traveling.

Portrait of Yunqi Hu

Yunqi Hu

PhD Candidate

Yunqi Hu is from Xining, Qinghai Province, China. She earned her bachelor’s degree from Ocean University of China, then completed her master’s degree and began her doctoral studies at Sun Yat-sen University. Her research in the Xu Lab focuses on intestinal mucosal immunity. Outside the lab, she enjoys watching TV series, doing handicrafts and singing.

Portrait of Jian Guo

Jian Guo

PhD Candidate

Jian Guo is from Ganzhou, Jiangxi Province, China. He earned his bachelor’s degree from the School of Life Sciences at Beijing Normal University and then moved to Sun Yat-sen University for his doctoral studies. His research in the Xu Lab focuses on aging and adaptive immunity. Outside the lab, he enjoys playing and watching football.

Portrait of Haimei Lv

Haimei Lv

PhD Candidate

Haimei Lv is from Guangdong, China. She studied biotechnology as an undergraduate at Southern Medical University and earned her master’s degree in Basic Medical Sciences at Sun Yat-sen University. Her research in the Xu Lab focuses on how systemic signals regulate plasma cells in the bone marrow. Outside the lab, she enjoys listening to music, watching movies and hiking.

Portrait of Jun Chen

Jun Chen

PhD Candidate

Jun Chen is from the Guangxi Zhuang Autonomous Region, China. He earned his bachelor’s degree from Heilongjiang University and his master’s degree from Shandong University. His research in the Xu Lab focuses on long-lived plasma cells and humoral immunity. Outside the lab, he enjoys good food, anime and movies.

Portrait of Yutong Xue

Yutong Xue

PhD Candidate

Yutong Xue is from Xi’an, Shaanxi Province, China. She earned her master’s degree in Internal Medicine (Hematology) from Nanfang Hospital, Southern Medical University, where she developed a strong interest in immunology and disease-related research. Her research in the Xu Lab focuses on humoral immunity, particularly the mechanisms that regulate it. Outside the lab, she enjoys traveling, listening to music and photography.

Portrait of Juan Xu

Juan Xu

PhD Candidate

Juan Xu is from Hengyang, Hunan Province, China. She holds a bachelor’s degree in Life Sciences from Hunan Normal University. Her research in the Xu Lab focuses on mucosal immunity in the mammary gland. Outside the lab, she enjoys shopping, hiking, cooking and watching short videos.

Portrait of Mengna Zhang

Mengna Zhang

PhD Candidate

Mengna Zhang is from Bozhou, Anhui, China. She earned a bachelor’s degree from Anhui Normal University and a master’s degree from Hangzhou Normal University. Her research in the Xu Lab focuses on immunology. Outside the lab, she enjoys cycling.

Master’s Students

Portrait of Jiamei Chen

Jiamei Chen

Master’s Student

Jiamei Chen is from Wuzhou, Guangxi, China. She earned her bachelor’s degree in Biological Sciences from Yunnan University. Her research in the Xu Lab focuses on the bone marrow microenvironment and humoral immunity. Outside the lab, she enjoys city walks, exploring local food and watching movies.

Portrait of Shuangshuang Liu

Shuangshuang Liu

Master’s Student

Shuangshuang Liu is from Nanchang, Jiangxi, China. She earned her bachelor’s degree in Biotechnology from Jiangxi Agricultural University. Her research in the Xu Lab focuses on mesenchymal stem cell (MSC) subpopulations and their role in shaping the immune microenvironment. Outside the lab, she enjoys sports, photography and dancing.

Portrait of Rui Ma

Rui Ma

Master’s Student

Rui Ma is from Guangzhou, Guangdong, China. He earned his bachelor’s degree from Xiamen University. His research in the Xu Lab focuses on how stress regulates humoral immunity. Outside the lab, he enjoys playing badminton, working out and listening to R&B and rap music.

Portrait of Duoduo Yun

Duoduo Yun

Master’s Student

Duoduo Yun is from Zhengzhou, Henan Province, China. She earned her bachelor’s degree in Biotechnology from Southern Medical University, where she carried out her thesis research. Her research in the Xu Lab focuses on the factors that determine how long the humoral immune response persists. Outside the lab, she enjoys dancing, outdoor sports and listening to music.

Lab Alumni