Xu Lab@Long-Lived Plasma Cells

Publications

Full list also on Google Scholar profile ↗

20263 papers

  1. Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells

    Zhu Y, Ding B, Lv H, Xu H, Chen J, Xu J, Wu Q, Hao X, Hu Y, Guo J, Chen J, Liang C, Li Y, Wu J, Cao N, Zhao J, Ren G, Jin H, Zhang Y, Li Y, Zhang H, Xu C

    Immunity 59(4):1006-1024.e7, 2026

    Highlighted by Nature Reviews Immunology (Link); Preview in Immunity (Link).

    DOI

  2. Inhibition of mitochondrial ROS by TACI sustains bone marrow plasma cells

    Zhu Y, Chen J, Lv H, Chen J, Tong Z, Hao X, Jing Z, Jiang H, Meng H, Yang C, Xu C

    Nature Communications 17:8546, 2026

    DOI

  3. Protocol for selective in vivo labeling of bone marrow plasma cells by intrafemoral antibody injection in mice

    Tong Z, Zhu Y, Lv H, Liu S, Xu C

    STAR Protocols 7(3), 2026

    DOI

20251 paper

  1. Haematopoietic stem cell number is not solely defined by niche availability

    Takeishi S, Marchand T, Koba WR, Borger DK, Xu C, Guha C, Bergman A, Frenette PS, Gritsman K, Steidl U

    Nature 646:687-696, 2025

    DOI

20223 papers

  1. Brain motor and fear circuits regulate leukocytes during acute stress

    Poller WC, Downey J, Mooslechner AA, Khan N, Li L, Chan CT, McAlpine CS, Xu C, Kahles F, He S, Janssen H, Mindur JE, Singh S, Kiss MG, Alonso-Herranz L, Iwamoto Y, Kohler RH, Wong LP, Chetal K, Russo SJ, Sadreyev RI, Weissleder R, Nahrendorf M, Frenette PS, Divangahi M, Swirski FK

    Nature, 2022

    DOI

  2. The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow

    Zhang D, Gao X, Li H, Borger DK, Wei Q, Yang E, Xu C, Pinho S, Frenette PS

    Cell Stem Cell 29(2):232-247, 2022

    DOI

  3. Mesenchymal stromal cells equipped by IFNα empower T cells with potent anti-tumor immunity

    Zhang T, Wang Y, Li Q, Lin L, Xu C, Xue Y, Hu M, Shi Y, Wang Y

    Oncogene 41(13):1866-1881, 2022

    DOI

20213 papers

  1. Nociceptive nerves regulate haematopoietic stem cell mobilization

    Gao X, Zhang D*, Xu C*, Li H, Caron KM, Frenette PS

    Nature 589(7843):591-596, 2021

    Equal contribution.

    DOI

  2. MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

    Wei Q, Pinho S, Dong S, Pierce H, Li H, Nakahara F, Xu J, Xu C, Boulais PE, Zhang D, Maryanovich M, Cuervo AM, Frenette PS

    Nature Communications 12:2522, 2021

    DOI

  3. Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage

    Xu C, Gulinello M, Frenette PS

    Journal of Experimental Medicine 218(1):e20200065, 2021

    Highlighted by Science Translational Medicine (Link).

    DOI

20203 papers

  1. The gut microbiome regulates psychological stress-induced inflammation

    Xu C, Lee SK, Zhang D, Frenette PS

    Immunity 53(2):417-428.e4, 2020

    Highlighted by Nature (Link); Preview in Immunity (Link); highlighted by Science Translational Medicine (Link).

    DOI

  2. Snai2 maintains bone marrow niche cells by repressing osteopontin expression

    Wei Q, Nakahara F, Asada N, Zhang D, Gao X, Xu C, Alfieri A, Brodin NP, Zimmerman SE, Mar JC, Guha C, Guo W, Frenette PS

    Developmental Cell 53(5):503-513.e5, 2020

    DOI

  3. Randomized Phase 2 trial of intravenous gamma globulin (IVIG) for the treatment of acute vaso-occlusive crisis in patients with sickle cell disease: lessons learned from the midpoint analysis

    Manwani D, Xu C, Lee SK, Amatuni G, Cohen H, Carullo V, Morrone K, Davila J, Shi PA, Ireland K, Keenan J, Frenette PS

    Complementary Therapies in Medicine 52:102481, 2020

    DOI

20193 papers

  1. Seasonal manifestations of sickle cell disease activity

    Xu C, Frenette PS

    Nature Medicine 25(4):536-537, 2019

    DOI

  2. Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

    Nakahara F, Borger DK, Wei Q, Pinho S, Maryanovich M, Zahalka A, Suzuki M, Cruz CD, Wang Z, Xu C, Boulais PE, Ma'ayan A, Greally J, Frenette PS

    Nature Cell Biology 21(5):560-567, 2019

    DOI

  3. The good side of inflammation: Staphylococcus aureus proteins SpA and Sbi contribute to proper abscess formation and wound healing during skin and soft tissue infections

    Gonzalez CD, Ledo C, Cela E, Stella I, Xu C, Ojeda DS, Frenette PS, Gomez M

    BBA - Molecular Basis of Disease 1865(10):2657-2670, 2019

    DOI

20182 papers

  1. The hematopoietic stem cell niche: from embryo to adult

    Gao X, Xu C, Asada N, Frenette PS

    Development 145(2), 2018

    DOI

  2. Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow

    Xu C, Gao X, Wei Q, Nakahara F, Zimmerman SE, Mar J, Frenette PS

    Nature Communications 9(1):2449, 2018

    DOI

20171 paper

  1. Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis

    Yu P, Huang Y, Xu C, Lin L, Han Y, Sun W, Hu G, Rabson AB, Wang Y, Shi Y

    Oncogene 36(6):840-849, 2017

    DOI

20165 papers

  1. Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

    Zhang D*, Xu C*, Manwani D*, Frenette PS

    Blood 127(7):801-809, 2016

    Equal contribution.

    DOI

  2. Efficient presentation of multiple endogenous epitopes to both CD4+ and CD8+ diabetogenic T cells for tolerance

    Dastagir SD*, Postigo-Fernandez J*, Xu C, Stoeckle J, Firdessa-Fite R, Creusot RJ

    Molecular Therapy - Methods & Clinical Development 4:27-38, 2016

    DOI

  3. Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells

    Shou P, Chen Q, Jiang J, Xu C, Zhang J, Zheng C, Jiang M, Velletri T, Cao W, Huang Y, Yang Q, Han X, Zhang L, Wei L, Rabson AB, Chin YE, Wang Y, Shi Y

    Oncogene 35(46):5953-5962, 2016

    DOI

  4. SHP1 regulates bone mass by directing mesenchymal stem cell differentiation

    Jiang M, Zheng C, Shou P, Li N, Cao G, Chen Q, Xu C, Du L, Yang Q, Cao J, Han Y, Li F, Cao W, Liu F, Rabson AB, Roberts AI, Xie W, Wang Y, Shi Y

    Cell Reports 16(3):769-780, 2016

    DOI

  5. Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

    Chen Q, Shou P, Zheng C, Jiang M, Cao G, Yang Q, Cao J, Xie N, Velletri T, Zhang X, Xu C, Zhang L, Yang H, Hou J, Wang Y, Shi Y

    Cell Death & Differentiation 23(7):1128-1139, 2016

    DOI

20152 papers

  1. Neutrophil ageing is regulated by the microbiome

    Zhang D, Chen G, Manwani D, Mortha A, Xu C, Faith J, Burk R, Kunisaki Y, Jang J, Scheiermann C, Merad M, Frenette PS

    Nature 525(7570):528-532, 2015

    DOI

  2. CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages

    Zheng C, Yang Q, Xu C, Shou P, Cao J, Jiang M, Chen Q, Cao Q, Han Y, Li F, Cao W, Zhang L, Zhang L, Shi Y, Wang Y

    PNAS 112(52):E7239-E7248, 2015

    DOI

20147 papers

  1. Transforming growth factor β promotes immune responses in the presence of mesenchymal stem cells

    Xu C, Yu P, Han X, Du L, Gan J, Wang Y, Shi Y

    Journal of Immunology 192(1):103-109, 2014

    Highlighted in the 'In This Issue' section.

    DOI

  2. Interleukin-17A enhances immunosuppression by mesenchymal stem cells

    Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Chen Q, Xu G, Zhang Y, Schneider R, Qian Y, Wang Y, Brewer G, Shi Y

    Cell Death and Differentiation 21(11):1758-1768, 2014

    DOI

  3. SSC-high CD11b-high Ly-6C-high Ly-6G-low myeloid cells curtail CD4 T cell response by inducing nitric oxide synthase in murine hepatitis

    Zhu K, Zhang N, Guo N, Yang J, Wang J, Yang C, Yang C, Zhu L, Xu C, Deng Q, Zhu R, Wang H, Chen X, Shi Y, Li Y, Leng Q

    International Journal of Biochemistry & Cell Biology 54:89-97, 2014

    DOI

  4. p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation

    Huang Y, Yu P, Li W, Ren G, Roberts A, Cao C, Zhang X, Su J, Chen X, Chen Q, Shou P, Xu C, Du L, Lin L, Xie N, Zhang L, Wang Y, Shi Y

    Oncogene 33(29):3830-3838, 2014

    DOI

  5. Mesenchymal stem cells prevent restraint stress-induced lymphocyte reduction via interleukin-4

    Cao G, Yang Q, Zhang S, Xu C, Wang Y, Shi Y

    Brain, Behavior, and Immunity 38:125-132, 2014

    DOI

  6. An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells

    Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao C, Roberts A, Robson A, Ren G, Zhang Y, Wang Y, Denhardt D, Shi Y

    Stem Cells 32(2):327-337, 2014

    DOI

  7. IFNα-secreting MSCs exert potent anti-tumor effect in vivo

    Xu C, Lin L, Cao G, Chen Q, Shou P, Huang Y, Han Y, Wang Y, Shi Y

    Oncogene 33(42):5047-5052, 2014

    DOI

20132 papers

  1. miR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2

    Xu C, Ren G, Cao G, Chen Q, Shou P, Zheng C, Du L, Han X, Jiang M, Yang Q, Lin L, Wang G, Yu P, Zhang X, Cao W, Brewer G, Wang Y, Shi Y

    Journal of Biological Chemistry 288(16):11074-11079, 2013

    DOI

  2. The research of the relationship between cyclooxygenase-2 and monocyte endothelial cells adhesion

    Wang H, Xu C, Cai F, Cao J, Chen X, Wu F

    Chinese Journal of Laboratory Diagnosis 17(10), 2013

    No DOI available.

20121 paper

  1. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα

    Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan ZR, Roberts AI, Zhang L, Zheng B, Wen T, Han Y, Rabson AB, Tischfield JA, Shao C, Shi Y

    Cell Stem Cell 11(6):812-824, 2012

    DOI

20101 paper

  1. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair

    Shi Y, Hu G, Su J, Li W, Chen Q, Shou P, Xu C, Chen X, Huang Y, Zhu Z, Huang X, Han X, Xie N, Ren G

    Cell Research 20(5):510-518, 2010

    DOI

20091 paper

  1. A single point mutation in E2 enhances hepatitis C virus infectivity and alters lipoprotein association of viral particles

    Tao W, Xu C, Ding Q, Li R, Xiang Y, Chung J, Zhong J

    Virology 395(1):67-76, 2009

    DOI